Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression ...
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What do cyclin-dependent kinases do exactly?
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
What drugs are cyclin-dependent kinase inhibitors?
There are currently three CDK4/6 inhibitors that have been approved by the US Food and Drug Administration: palbociclib, ribociclib, and abemaciclib.
What are cyclin-dependent kinases quizlet?
Cyclin-dependent kinases. a group of protein kinases that are activated by the formation of a complex with a cyclin and are involved in the regulation of the cell cycle.
What are the three types of CDKs?
The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20).
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine ...
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A cyclin-dependent kinase complex (CDKC, cyclin-CDK) is a protein complex formed by the association of an inactive catalytic subunit of a protein kinase, ...
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Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the ...
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A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell ...
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It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as ...
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Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene.
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Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. CDK9. Available structures. PDB, Ortholog search: PDBe RCSB. List of ...
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