Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. CCND1. Available structures. PDB, Ortholog search: PDBe RCSB. List of PDB id codes.
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What does it mean when your cyclin D1 is positive?
Positive expression of cyclin D1 is an indicator for the evaluation of the prognosis of breast cancer - PMC. The .gov means it's official. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
What does cyclin D1 do?
Cyclin D1 is mostly known for the role played in the nucleus, as regulator of cell cycle progression. Cyclin D1 modulates the transition from G1 to S phase through its action as allosteric regulator of the cyclin-dependent kinase 4 (CDK) and CDK6.
What cancer is cyclin D1 overexpression in?
Amplification and overexpression of CCND1 preferentially occurred in estrogen receptor (ER)-positive breast cancer [56,57,58,59]. Notably, the amplification of CCND1 is related to the poor prognosis of ER-positive breast cancer and ER-positive tamoxifen-treated breast cancer [4, 60,61,62].
What is the function of cyclin A CDK1?
Cyclin A–CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry. Cyclin A and CDC25A are both activators of cyclin-dependent kinases (CDKs): cyclin A acts as an activating subunit of CDKs and CDC25A a phosphatase of the inhibitory phosphorylation sites of the CDKs.
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 ...
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Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Tertiary structure of human ...
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Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression ...
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Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine ...
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Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the ...
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Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes ...
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This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the ...
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